Regulation of the IL-21 Gene by the NF-kB Transcription Factor c-Rel
نویسندگان
چکیده
منابع مشابه
Induction of Heme Oxygenase -1 By Lipocalin 2 Mediated By Nf-Kb Transcription Factor
Purpose: Effect of lipocalin 2 on the expression of heme oxygenase I , II and NF-kB transcription factor was the purpose of this survey. Materials and Methods: Lcn2 was cloned to pcDNA3.1 plasmid by using genetic engineering method. The recombinant vector was transfected to CHO and HEK293T to establish stable cell expressing lipocalin 2. The presence of lipocalin 2 gene in these cells was confi...
متن کاملRegulation of the IL-21 gene by the NF-κB transcription factor c-Rel.
IL-21 is a member of the common gamma-chain-dependent cytokine family and is a key modulator of lymphocyte development, proliferation, and differentiation. IL-21 is highly expressed in activated CD4(+) T cells and plays a critical role in the expansion and differentiation of the Th cell subsets, Th17 and follicular helper T (T(FH)) cells. Because of its potent activity in both myeloid and lymph...
متن کاملW - KB Subunit - specific Regulation of the IKBCU Promoter *
Stimulation of endothelial cells by cytokines and bacterial lipopolysaccharide leads to activation f the transcription factor NF-KB. NF-KB in turn regulates the expression of several genes involved in the inflammatory reaction, including cell adhesion molecules, interleukins, and transcription factors. One of these induced genes encodes an inhibitor of NF-KB, ECI-~/IKB~, that contains in its 5‘...
متن کاملActivation of the Transcriptional Function of the NF-kB Protein c-Rel by O-GlcNAc Glycosylation
D ow nladed fr The transcription factor nuclear factor kB (NF-kB) rapidly reprograms gene expression in response to various stimuli, and its activity is regulated by several posttranslational modifications, including phosphorylation, methylation, and acetylation. The addition of O-linked b-N-acetylglucosamine (a process known as O-GlcNAcylation) is an abundant posttranslational modification tha...
متن کاملRegulation of Interleukin 12 p40 Expression through an NF-kB Half-Site
Interleukin 12 (IL-12) is an inducible cytokine composed of 35and 40-kDa subunits that is critical for promoting T helper type 1 development and cell-mediated immunity against pathogens. The 40-kDa subunit, expressed by activated macrophages and B cells, is induced by several pathogens in vivo and in vitro and is augmented or inhibited by gamma interferon (IFN-g) or IL-10, respectively. Control...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2010